Article

The Impacts of G4S Mutation on N-glycosylation and conformation of the Human Coagulation Factor IX GLA domain: In silico and In vitro Analysis

2021-12-03

Abstract excerpt

<title>Abstract</title> <p>Missense mutations are the most prevalent form of mutation in hemophilia B patients. These alterations may result in the creation of novel and non-native N-glycosylation sites (Asn-X-Ser/Thr) through single amino acid substitutions. The pathogenic mechanisms of N-glycosylation mutations in hemophilia B patients have not been extensively studied yet. By survey among known missense mutati...

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Literature Corpus work: 363fa6ab-34c7-54a1-aa6e-eebcf500837f
DOI: 10.21203/rs.3.rs-1071688/v1

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