Article

Encapsulated Bacteria with a Light-Repressed Deadman Switch for Liver Gene Delivery

2024-09-24

Abstract excerpt

Adeno-associated viruses (AAVs) have been used for liver gene therapy. Hemgenix and Roctavian are AAV-based treatments for hemophilia B and A, respectively. They cost $3 million and $2.8 million per dose, respectively. While AAV vectors may eventually be cheaper to mass produce, a bacteria-based DNA delivery system might be much cheaper for patients. Also, “bactofection” would allow for the delivery of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3526c8cd-1003-5534-afbf-5ec1b240effe
DOI: 10.20944/preprints202404.1631.v5

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest

Encapsulated Bacteria with a Light-Repressed Deadman Switch for Liver Gene DeliveryDOI 10.20944/preprints202404.1631.v5Read

Sequence-independent, site-specific incorporation of chemical modifications to generate light-activated plasmidsSemantic proximity Read

Capsid Engineering of Adenovirus Vectors: Overcoming Early Vector–Host Interactions for TherapySemantic proximity Read

Magneto-Photonic Gene Circuit for Minimally Invasive Control of Gene Expression in Mammalian CellsSemantic proximity Read

Gene therapy: light is finally in the tunnel.Semantic proximity Read

Manufacturing of recombinant adeno-associated viral vectors: new technologies are welcomeSemantic proximity Read

The evolution of heart gene delivery vectorsSemantic proximity Read

Acoustically Detonated Biomolecules for Genetically Encodable Inertial CavitationSemantic proximity Read

The deLIVERed promises of gene therapy: Past, present, and future of liver-directed gene therapySemantic proximity Read