Article

Transcriptome analyses of β-thalassemia -28 (A>G) mutation using isogenic cell models generated by CRISPR/Cas9 and asymmetric single-stranded oligodeoxynucleotides (assODN)

2020-06-18

Abstract excerpt

β-thalassemia, caused by mutations in the human hemoglobin ( HBB ) gene, is one of the most common genetic diseases in the world. HBB –28 (A>G) mutation is one of the five most common mutations in China patients with β-thalassemia. However, few studies have been conducted to understand how this mutation affects the expression of pathogenesis related genes including globin genes due to limited homologous clinical...

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Literature Corpus work: 34341edd-9aca-5eb4-8544-f7b101b4a6d5
DOI: 10.1101/2020.06.18.159004

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