Efficacy and potential human and economic impact of a broadly protective betacoronavirus vaccine

Abstract excerpt

Within two decades, three different betacoronaviruses (β-CoV) have spilled over from animals to humans causing high consequence diseases, the most recent causing the COVID-19 pandemic. Using computational antigen design technology, we developed a single multivalent vaccine candidate capable of broadly neutralising diverse animal and human β-CoVs. We then demonstrated that this single vaccine could protect mice fro...

Topics

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• Herpesvirus Infections and Treatments
• HIV Research and Treatment
• Immunotherapy and Immune Responses
• Mosquito-borne diseases and control
• Poxvirus research and outbreaks
• SARS-CoV-2 and COVID-19 Research
• vaccines and immunoinformatics approaches
• Viral Infections and Outbreaks Research

Identifiers and source

Literature Corpus work

33d2c94f-3273-582f-bc89-af7f3749bcf1

DOI

10.1101/2025.10.17.25338244