Article

Granzyme B-based CAR T cells block metastasis by eliminating circulating tumor cells

2024-03-19

Abstract excerpt

Chimeric antigen receptor (CAR) T cells have limited efficacy against solid tumors due to the hostile microenvironment. Circulating tumor cells (CTCs) are essential to metastasis, which is the cause of most of cancer-related death. Here, we generated GrB-CAR T cells targeting membrane-bound HSP70 (mHSP70), a highly tumor-specific antigen detected in numerous cancers. GrB-CAR T cells exhibited potent cytotoxicity a...

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Literature Corpus work: 33c33baa-7ce5-54dd-a566-feab2cf9d0b0
DOI: 10.1101/2024.03.18.585442

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