Article

The breast tumor microenvironment exploits eosinophil plasticity to suppress their anti-tumor activity

2026-01-12

Abstract excerpt

Eosinophils recently emerged as mediators of anti-tumor immunity in immune checkpoint blockade (ICB) treated breast cancer patients. Yet, their role in the treatment-naïve breast tumor microenvironment (TME) remains elusive. Here, we show that the breast TME shapes eosinophils into a less active state characterized by loss of Ly6C. While bone marrow and circulating eosinophils are Ly6C⁺, this population progressiv...

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Literature Corpus work: 32afbd07-0ce8-5c28-8823-9ecf3c293010
DOI: 10.64898/2026.01.12.698961

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