A tissue multiplexing approach to maximise spatial transcriptomics output from precious pathology specimens

Abstract excerpt

Since diagnostic specimens retrieved from pathology cannot be altered (except for sectioning) for ethicolegal reasons, we describe a method that combines multiple patient specimens, cut from individual blocks, allowing the measurement of several tissues in one capture array. This results in a cost-effective means to increase sample size to permit statistically robust data outputs and to fast-track clinical impleme...

Topics

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• Epidermis
• Gene expression and cancer classification
• Gene Expression Profiling
• Phenotype
• Skin
• Technology
• Transcriptome
• Vitiligo

Identifiers and source

Literature Corpus work

32a268fe-d0d1-54fe-b846-f5311315cc32

DOI

10.1101/2025.02.06.25321364