Article

Domain- and Lineage-Specific Heterogeneity in Selective Constraint on Gliomedin (GLDN), a Node of Ranvier Gene Restricted to Jawed Vertebrates

2026-08-18

Abstract excerpt

<title>Abstract</title> <p>Almost every protein-coding gene sits under some degree of purifying selection, so a single gene-wide dN/dS value tells us little on its own. The more useful question is where the constraint sits: in which domain, on which lineages, and over what phylogenetic depth the gene can be traced at all. We took gliomedin (GLDN) as a test case. GLDN is the Schwann cell-derived glial ligand for t...

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Literature Corpus work: 329b01b5-8551-526b-b319-b178f1125e26
DOI: 10.21203/rs.3.rs-10729704/v1

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Domain- and Lineage-Specific Heterogeneity in Selective Constraint on Gliomedin (GLDN), a Node of Ranvier Gene Restricted to Jawed VertebratesDOI 10.21203/rs.3.rs-10729704/v1Read

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