Article

Threshold of somatic mosaicism disrupting the brain function

2023-12-30

Abstract excerpt

Somatic mosaicism in a fraction of brain cells causes neurodevelopmental disorders, including childhood intractable epilepsy. However, the threshold for somatic mosaicism leading to brain dysfunction is unknown. In this study, we induced various mosaic burdens in mice of focal cortical dysplasia type II (FCD II), featuring mTOR somatic mosaicism and spontaneous behavioral seizures. Mosaic burdens ranged from appro...

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Literature Corpus work: 31b17a25-2cd9-57bf-a07e-3462674537a9
DOI: 10.1101/2023.12.30.573716

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