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Multi-omics Analysis of Umbilical Cord Hematopoietic Stem Cells from a Multi-ethnic Cohort of Hawaii Reveals the Intergenerational Effect of Maternal Pre-Pregnancy Obesity and Risk Prediction for Cancers

2024-07-27

Abstract excerpt

<h4>Background</h4> Maternal obesity is a health concern that may predispose newborns to a high risk of medical problems later in life. To understand the intergenerational effect of maternal obesity, we hypothesized that the maternal obesity effect is mediated by epigenetic changes in the CD34+/CD38−/Lin− hematopoietic stem cells (uHSCs) in the offspring. Towards this, we conducted a DNA methylation centric multi-...

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Literature Corpus work: 3181a6b7-2e09-5d4e-bb07-46e3adb01bea
DOI: 10.1101/2024.07.27.24310936

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Multi-omics Analysis of Umbilical Cord Hematopoietic Stem Cells from a Multi-ethnic Cohort of Hawaii Reveals the Intergenerational Effect of Maternal Pre-Pregnancy Obesity and Risk Prediction for CancersDOI 10.1101/2024.07.27.24310936Read

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