Article

CLAMP: Curated Latent-variable Analysis with Molecular Priors

2025-06-09

Abstract excerpt

Gene expression analysis has long been fundamental for elucidating molecular pathways and gene-disease relationships, but traditional single-gene approaches cannot capture the coordinated regulatory networks underlying complex phenotypes; although unsupervised matrix factorization methods (e.g., PCA, NMF) reveal coexpression patterns, they lack the ability to incorporate prior biological knowledge and often strugg...

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Literature Corpus work: 31175186-2faa-5c46-9313-a1a8f95bab2b
DOI: 10.1101/2025.06.05.658122

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