Article

The Role Of Early TP53 Mutations On The Evolution Of Therapy-Related AML

2013-11-15

Abstract excerpt

Abstract Therapy-related acute myeloid leukemia (t-AML) and therapy-related myelodysplastic syndrome (t-MDS) are well-recognized complications of cytotoxic chemotherapy and/or radiotherapy. Compared to de novo AML, there is a higher incidence of TP53 mutations, abnormalities of chromosomes 5 or 7, and complex cytogenetics in t-AML. The response to chemotherapy is also reduced compared to de novo AML, and long-term...

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Literature Corpus work: 30cb1a24-5c2a-5fc1-b280-65d746a98af7
DOI: 10.1182/blood.v122.21.5.5

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