Article
Mutational profiling of therapy-related myelodysplastic syndromes and acute myeloid leukemia by next generation sequencing, a comparison with de novo diseases.
Leukemia research - 1 Mar 2015
Ok Chi Young, Patel Keyur P, Garcia-Manero Guillermo, Routbort Mark J, Fu Bin, Tang Guilin, Goswami Maitrayee, Singh Rajesh, Kanagal-Shamanna Rashmi, Pierce Sherry A, Young Ken H, Kantarjian Hagop M, Medeiros L Jeffrey, Luthra Rajyalakshmi, Wang Sa A
Abstract excerpt
In this study we used a next generation sequencing-based approach to profile gene mutations in therapy-related myelodysplastic syndromes (t-MDS) and acute myeloid leukemia (t-AML); and compared these findings with de novo MDS/AML. Consecutive bone marrow samples of 498 patients, including 70 therapy-related (28 MDS and 42 AML) and 428 de novo (147 MDS and 281 AML) were analyzed using a modified-TruSeq Amplicon...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.