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Facility-Level Mutation Fingerprints and Early-Warning Surveillance of Drug-Resistant Mycobacterium tuberculosis in Rural Eastern Cape

2026-02-25

Abstract excerpt

<title>Abstract</title> <p> Background Routine molecular tuberculosis (TB) diagnostics generate high-dimensional "off-protocol" data, including mutant melt peak temperatures and cycle threshold (CT) values. These data are currently underutilized, typically discarded after individual resistance reporting. We aimed to evaluate whether aggregating these routine "mutation-proxy" signals could provide a scalable fra...

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Literature Corpus work
2fecf02c-465a-56aa-8a17-b4f1ad21b5d6
DOI
10.21203/rs.3.rs-8790685/v1
Open publication

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