Article

Multiomics and quantitative modelling disentangle diet, host, and microbiota contributions to the host metabolome

2022-08-15

Abstract excerpt

Dietary nutrients, host metabolism, and gut microbiota activity each influence the host’s metabolic phenotype; however, the interplay between these factors remains poorly understood. We employed tissue-resolved metabolomics in gnotobiotic mice carrying a synthetic human gut microbiota and germfree mice in two dietary conditions to develop an intestinal flux model that quantifies diet, host, and bacterial contribut...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2fa93ffb-988e-50c3-9978-28f2c5d3bbf0
DOI: 10.1101/2022.08.15.503927

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multiomics and quantitative modelling disentangle diet, host, and microbiota contributions to the host metabolomeDOI 10.1101/2022.08.15.503927Read

The gut microbiota modulates host amino acid and glutathione metabolism in miceSemantic proximity Read

From next-generation sequencing to systematic modeling of the gut microbiomeSemantic proximity Read

Gut microbiota functions: metabolism of nutrients and other food componentsSemantic proximity Read

The complex interplay of diet, xenobiotics, and microbial metabolism in the gut: Implications for clinical outcomesSemantic proximity Read

Metabolic Modeling of Human Gut Microbiota on a Genome Scale: An OverviewSemantic proximity Read

Tissue-wide metabolomics reveals wide impact of gut microbiota on mice metabolite compositionSemantic proximity Read

Moving beyond descriptive studies: harnessing metabolomics to elucidate the molecular mechanisms underpinning host-microbiome phenotypes.Semantic proximity Read

Systematic prediction of health-relevant human-microbial co-metabolism through a computational frameworkSemantic proximity Read

Simplified Intestinal Microbiota to Study Microbe-Diet-Host Interactions in a Mouse ModelSemantic proximity Read

gutMGene v2.0: an updated comprehensive database for target genes of gut microbes and microbial metabolitesSemantic proximity Read

Metagenome-scale community metabolic modelling for understanding the role of gut microbiota in human healthSemantic proximity Read

Complete genome-derived metabolic interactions reveal impact of gut ecology on human healthSemantic proximity Read