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Article

Site-specific labeling of SBDS to monitor interactions with the 60S ribosomal subunit.

Methods (San Diego, Calif.) - 1 Mar 2023

Biswas Aparna, Peng Yu-Fong, Kaushik Vikas, Origanti Sofia

Abstract excerpt

The Shwachman-Diamond syndrome (SDS) is a rare inherited ribosomopathy that is predominantly caused by mutations in the Shwachman-Bodian-Diamond Syndrome gene (SBDS). SBDS is a ribosomal maturation factor that is essential for the release of eukaryotic translation initiation factor 6 (eIF6) from 60S ribosomal subunits during the late stages of 60S maturation. Release of eIF6 is critical to permit inter-subunit...

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Identifiers

PMID: 36781034
DOI: 10.1016/j.ymeth.2023.02.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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