Back to search

Article

Ruxolitinib for Glucocorticoid-Refractory Chronic Graft-versus-Host Disease

2021-07-14

Abstract excerpt

BACKGROUND Chronic graft-versus-host disease (GVHD), a major complication of allogeneic stem-cell transplantation, becomes glucocorticoid-refractory or glucocorticoid-dependent in approximately 50% of patients. Robust data from phase 3 randomized studies evaluating second-line therapy for chronic GVHD are lacking. In retrospective surveys, ruxolitinib, a Janus kinase (JAK1-JAK2) inhibitor, showed potential efficac...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
2e840e5f-43f3-50f2-9628-6e158877fd7e
DOI
10.1056/nejmoa2033122
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Ruxolitinib for Glucocorticoid-Refractory Chronic Graft-versus-Host DiseaseDOI 10.1056/nejmoa2033122
Emerging novel therapies for steroid-refractory acute graft-versus-host disease: recent advances and future directionsSemantic proximity
Evaluation of Ruxolitinib for Steroid-Refractory Chronic Graft-vs-Host Disease After Allogeneic Hematopoietic Stem Cell TransplantationSemantic proximity
Evaluating Axatilimab as a treatment option for chronic graft-versus-host diseaseSemantic proximity
Graft-versus-host diseaseSemantic proximity
Chronic graft-versus-host diseaseSemantic proximity
New molecules in the therapy of chronic graft-versus-host diseaseSemantic proximity
Steroid Refractory Chronic Graft-Versus-Host Disease: Cost-Effectiveness AnalysisSemantic proximity
Emerging Therapeutics for the Control of Chronic Graft-versus-Host DiseaseSemantic proximity
Current Challenges in Chronic Graft-versus-Host DiseaseSemantic proximity
Effect of systemic glucocorticoid immunosuppression timing, dose, and duration on overall survival among immune checkpoint inhibitor recipients: a retrospective multicohort studySemantic proximity
Ruxolitinib versus Dexamethasone in Hospitalized Adults with Covid-19: multicenter matched-controlled studySemantic proximity
Belumosudil for Chronic Graft-Versus-Host Disease: Analysis of Long-Term Results from the KD025-208 and ROCKstar StudiesSemantic proximity
Select a neighboring publication to make it the new centre.