Article

Bioelectronic Zeitgebers: targeted neuromodulation to re-establish circadian rhythms

2023-04-30

Abstract excerpt

Existing neurostimulation systems implanted for the treatment of neurodegenerative disorders generally deliver invariable therapy parameters, regardless of phase of the sleep/wake cycle. However, there is considerable evidence that brain activity in these conditions varies according to this cycle, with discrete patterns of dysfunction linked to loss of circadian rhythmicity, worse clinical outcomes and impaired pa...

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Literature Corpus work: 2e7af1b5-2df5-5ed7-ab48-ab09df945c43
DOI: 10.1101/2023.04.30.538861

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