Article

Biocompatible polymers for scalable production of human neural organoids

2022-03-18

Abstract excerpt

The generation of neural organoids from human pluripotent stem cells holds great promise in modeling disease and screenings drugs, but current approaches are difficult to scale due to undesired organoid fusion. Here, we develop a scalable neural organoid platform by screening biocompatible polymers that prevent fusion of organoids cultured in suspension. We show that addition of one inexpensive polysaccharide enab...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2dfba20e-6796-5d56-9ebf-0153393b3d7e
DOI: 10.1101/2022.03.18.484949

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Biocompatible polymers for scalable production of human neural organoidsDOI 10.1101/2022.03.18.484949Read

Neural organoids for disease phenotyping, drug screening and developmental biology studies.Semantic proximity Read

Rapid Induction of Cerebral Organoids From Human Induced Pluripotent Stem Cells Using a Chemically Defined Hydrogel and Defined Cell Culture MediumSemantic proximity Read

Uniform cerebral organoid culture on a pillar plate by simple and reproducible spheroid transfer from an ultralow attachment well plateSemantic proximity Read

Optimizing PSC culture for generating neural organoidsSemantic proximity Read

The future of cerebral organoids in drug discovery.Semantic proximity Read

Unified Generation of Regionalized Neural Organoids from Single-Lumen NeuroepitheliumSemantic proximity Read

An orthogonal differentiation platform for genomically programming stem cells, organoids, and bioprinted tissuesSemantic proximity Read

Robust Production of Uniform Human Cerebral Organoids from Pluripotent Stem CellsSemantic proximity Read

Long-term expansion, genomic stability and in vivo safety of adult human pancreas organoidsSemantic proximity Read

Strategies for Generating Human Pluripotent Stem Cell- Derived-Organoid Culture for Disease Modelling, Drug Screening, and Regenerative TherapySemantic proximity Read

Long-term expansion, genomic stability, in vivo safety and immunogenicity of adult human pancreas organoidsSemantic proximity Read

Differentiation of cortical brain organoids and optic nerve-like structures from retinal confluent cultures of pluripotent stem cellsSemantic proximity Read