Article

KIF1A-mediated trafficking is required for neuronal autophagy in human neurons

2026-07-24

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in the molecular motor protein KIF1A result in a spectrum of neurodevelopmental and neurodegenerative disorders termed KIF1A-Associated Neurological Disorder (KAND). KIF1A mutations variably disrupt synaptic vesicle trafficking, but the effects of KIF1A mutations on other trafficking pathways remain unexplored. Autophagy is a conserved pathway required for neuronal homeostasis. We inve...

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Literature Corpus work: 7995bcac-404d-5df3-b79d-a218c4f97338
DOI: 10.64898/2026.07.22.740140

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