Article

Partial prion cross-seeding between fungal and mammalian amyloid signaling motifs

2020-07-22

Abstract excerpt

In filamentous fungi, NLR-based signalosomes activate downstream membrane-targeting cell-death inducing proteins by a mechanism of amyloid templating. In the species Podospora anserina , two such signalosomes, NWD2/HET-S and FNT1/HELLF have been described. An analogous system, involving a distinct amyloid signaling motif termed PP was also identified in the genome of the species Chaetomium globosum and studied u...

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Literature Corpus work: 2d4192ed-2c1a-57fa-bffd-08690a9ad013
DOI: 10.1101/2020.07.22.215483

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