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Trimethylamine modulates dauer formation, neurodegeneration, and lifespan through tyra-3/daf-11 signaling in Caenorhabditis elegans.

Aging cell - 1 May 2021

Khanna Amit, Sellegounder Durai, Kumar Jitendra, Chamoli Manish, Vargas Miguel, Chinta Shankar J, Rane Anand, Nelson Christopher, Peiris T Harshani, Brem Rachel, Andersen Julie, Lithgow Gordon, Kapahi Pankaj

Abstract excerpt

In the nematode Caenorhabditis elegans, signals derived from bacteria in the diet, the animal's major nutrient source, can modulate both behavior and healthspan. Here we describe a dual role for trimethylamine (TMA), a human gut flora metabolite, which acts as a nutrient signal and a neurotoxin. TMA and its associated metabolites are produced by the human gut microbiome and have been suggested to serve as risk...

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PMID: 33819374
DOI: 10.1111/acel.13351
PMCID: PMC8135002

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