Article

Myeloid <i>Zfhx3</i> Deficiency Protects Against Hypercapnia-induced Suppression of Host Defense Against Influenza A Virus

2023-03-01

Abstract excerpt

<h4>Summary</h4> Hypercapnia, elevation of the partial pressure of CO 2 in blood and tissues, is a risk factor for mortality in patients with severe acute and chronic lung diseases. We previously showed that hypercapnia inhibits multiple macrophage and neutrophil antimicrobial functions, and that elevated CO 2 increases the mortality of bacterial and viral pneumonia in mice. Here, we show that normoxic hypercap...

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Literature Corpus work: 2c5a0df8-c8c7-5a0d-b597-a45f51c56518
DOI: 10.1101/2023.02.28.530480

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