Article

Simultaneously evaluating efficacy and cardiotoxicity of EGFR-TKI AC0010 with a novel multifunctional biosensor

2022-12-09

Abstract excerpt

Non-small lung cancer (NSCLC) is a leading cause of cancer mortality worldwide. Although epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have dramatically improved life expectancy for NSCLC patients, concerns about TKI-induced cardiotoxicities increased. AC0010, a novel third-generation TKI, was developed to overcome acquired EGFR-T790M mutation-induced drug resistance. However, the cardiot...

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Literature Corpus work: 2c128d4e-bc52-594b-b423-c6b2dc1e1787
DOI: 10.21203/rs.3.rs-2146794/v1

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