Article

Natural compounds as potential PI3K-AKT1 signaling pathway inhibitors by means of pharmacophore modeling

2016-07-06

Abstract excerpt

AKT1, a modulator of PI3K-AKT1 pathway, is dysregulated in several human diseases, and understanding deeper its role in the complexity of biological systems remains an important goal. The research has been focused on development and study of potential synthetic-natural allosteric inhibitors for AKT1, and recent studies have shown how some natural compounds may play this role (1). We are interested in a screening o...

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Literature Corpus work: 2bfad6a1-07a2-5cc4-b08b-010f257949f1
DOI: 10.7287/peerj.preprints.2254v1

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