Early alterations in cortical and cerebellar regional brain growth in Down Syndrome: An in-vivo fetal and neonatal MRI assessment

Abstract excerpt

Down Syndrome (DS) is the most frequent genetic cause of intellectual disability with a wide spectrum of neurodevelopmental outcomes. At present, the relationship between structural brain morphology and the spectrum of cognitive phenotypes in DS, is not well understood. This study aimed to quantify development of the fetal and neonatal brain in DS using dedicated, optimised and motion-corrected in-vivo magnetic r...

Topics

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• Attention
• Cognition
• Down Syndrome
• Down syndrome and intellectual disability research
• Emotions
• Fetal and Pediatric Neurological Disorders
• Genomic variations and chromosomal abnormalities
• Prenatal Screening and Diagnostics

Identifiers and source

Literature Corpus work

2be7d8db-f521-596f-87f5-69d5120d8b2a

DOI

10.1101/683656