Article

Identification of genetic pathways driving Ebola virus disease in humans and targets for therapeutic intervention

2016-12-02

Abstract excerpt

<h4>Introduction: </h4> LCK gene, also known as lymphocyte-specific proto-oncogene, is expressed in lymphocytes, and associated with coordinated expression of MHC class I and II in response to physiological stimuli, mediated through a combined interaction of promoters, suppressors, and enhancers. Differential usage of LCK promoters, transcribes dysfunctional transcript variants leading to leukemogenesis and non-i...

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Literature Corpus work: 2b0f6d59-8e7f-5a16-924a-59ca3e2d009f
DOI: 10.12688/f1000research.9778.1

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