Article

Unc 51–like autophagy-activating kinase (ULK1) mediates clearance of free α-globin in β-thalassemia

2018-10-26

Abstract excerpt

Erythroid maturation is coordinated to maximize the production of hemoglobin A heterotetramers (α2β2) and minimize the accumulation of potentially toxic free α- or β-globin subunits. In β-thalassemia, mutations in the β-globin gene cause a build-up of free α-globin, which forms intracellular precipitates that impair erythroid cell maturation and viability. Protein quality-control systems mitigate β-thalassemia pat...

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Literature Corpus work: 2a545e2a-de13-53b8-8396-9d5981efd724
DOI: 10.1101/454652

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