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Article

Integrated protein quality-control pathways regulate free α-globin in murine β-thalassemia.

Blood - 31 May 2012

Khandros Eugene, Thom Christopher S, D'Souza Janine, Weiss Mitchell J

Abstract excerpt

Cells remove unstable polypeptides through protein quality-control (PQC) pathways such as ubiquitin-mediated proteolysis and autophagy. In the present study, we investigated how these pathways are used in β-thalassemia, a common hemoglobinopathy in which β-globin gene mutations cause the accumula...

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Identifiers

PMID: 22427201
DOI: 10.1182/blood-2011-12-397729
PMCID: PMC3369615

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22427201-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Integrated protein quality-control pathways regulate free α-globin in murine β-thalassemia.PMID 22427201Read ↗

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