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Aggrephagy Deficiency in the Placenta: A New Pathogenesis of Preeclampsia

28 Feb 2021

Abstract excerpt

Aggrephagy is defined as the selective degradation of aggregated proteins by autophagosomes. Protein aggregation in organs and cells has been highlighted as a cause of multiple diseases, including neurodegenerative diseases, cardiac failure, and renal failure. Aggregates could pose a hazard for cell survival. Cells exhibit three main mechanisms against the accumulation of aggregates: protein refolding by...

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PMID: 33670947
DOI: 10.3390/ijms22052432

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