Article

Coalescence and Translation: A Language Model for Population Genetics

2025-06-27

Abstract excerpt

Probabilistic models such as the sequentially Markovian coalescent (SMC) have long provided a powerful framework for population genetic inference, enabling reconstruction of demographic history and ancestral relationships from genomic data. However, these methods are inherently specialized, relying on predefined assumptions and/or limited scalability. Recent advances in simulation and deep learning provide an alte...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 297ac73a-cac0-5a4a-86b9-191eb1a3fa39
DOI: 10.1101/2025.06.24.661337

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Coalescence and Translation: A Language Model for Population GeneticsDOI 10.1101/2025.06.24.661337Read

Coalescence and translation: A language model for population genetics.Semantic proximity Read

Ancestral Population Genomics with Jocx, a Coalescent Hidden Markov Model.Semantic proximity Read

Automatic inference of demographic parameters using Generative Adversarial NetworksSemantic proximity Read

This population does not exist: learning the distribution of evolutionary histories with generative adversarial networksSemantic proximity Read

Efficient ancestry and mutation simulation with msprime 1.0.Semantic proximity Read

Ancestral population genomics: the coalescent hidden Markov model approach.Semantic proximity Read

Inference of Coalescence Times and Variant Ages Using Convolutional Neural Networks.Semantic proximity Read

SIA: Selection Inference Using the Ancestral Recombination GraphSemantic proximity Read

Variational Inference Using Approximate Likelihood Under the Coalescent With RecombinationSemantic proximity Read

Demographic inference from multiple whole genomes using a particle filter for continuous Markov jump processes.Semantic proximity Read

Computing coalescence rates for complex demographies and sampling configurationsSemantic proximity Read

Estimation of demography and mutation rates from one million haploid genomes.Semantic proximity Read