Article

Host factors drive the within-host competition between highly and low pathogenic H5N8 avian influenza viruses

2021-04-06

Abstract excerpt

<h4>ABSTRACT</h4> Highly pathogenic avian influenza viruses (HPAIV) emerge from low pathogenic avian influenza viruses (LPAIV) through the introduction of basic amino acids at the hemagglutinin (HA) cleavage site. Following viral evolution, the newly formed HPAIV likely represents a minority variant within the index host, predominantly infected with the LPAIV precursor. Using reverse-genetics engineered H5N8 viru...

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Literature Corpus work: 29710050-0406-51f2-b280-fb945f761206
DOI: 10.1101/2021.04.06.438580

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