Article
Opposite Outcomes of the Within-Host Competition between High- and Low-Pathogenic H5N8 Avian Influenza Viruses in Chickens Compared to Ducks.
Journal of virology - 12 Jan 2022
Bessière Pierre, Figueroa Thomas, Coggon Amelia, Foret-Lucas Charlotte, Houffschmitt Alexandre, Fusade-Boyer Maxime, Dupré Gabriel, Guérin Jean-Luc, Delverdier Maxence, Volmer Romain
Abstract excerpt
Highly pathogenic avian influenza viruses (HPAIV) emerge from low-pathogenic avian influenza viruses (LPAIV) through the introduction of basic amino acids at the hemagglutinin (HA) cleavage site. Following viral evolution, the newly formed HPAIV likely represents a minority variant within the index host, predominantly infected with the LPAIV precursor. Using reverse genetics-engineered H5N8 viruses differing...
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