Article

When scalar endpoints cannot identify multidomain stabilization: estimand-aligned trajectory summaries for chronic longitudinal trials

2026-08-07

Abstract excerpt

<title>Abstract</title> <p>Many chronic conditions involve interacting symptom, functional, and physiological domains measured repeatedly over time. Randomized trials frequently summarize efficacy using baseline-to-endpoint contrasts in a designated primary domain. When the clinical question concerns sustained multidomain stabilization rather than single-domain magnitude change, it is uncertain whether scalar end...

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Literature Corpus work: 28aab25f-b922-54ba-aa7a-7b7e4279973e
DOI: 10.21203/rs.3.rs-10257645/v1

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