Article

Inhibition of BIRC5 and MCL1 as a potential treatment strategy to overcome drug resistance in Mantle Cell Lymphoma

2025-04-11

Abstract excerpt

<h4>ABSTRACT</h4> Mantle cell lymphoma (MCL) is a difficult-to-cure, highly heterogeneous, and aggressive form of non-Hodgkin lymphoma with a high recurrence rate and poor long-term prognosis. Using a novel optimization-regularization-based computational prediction algorithm called “secDrug,” we have identified therapeutic targets for treating resistant cancers. When applied to B-cell malignancies, the secDrug al...

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Literature Corpus work: 288d8ffe-d7d3-53b4-acc5-7b3c1e22cbc1
DOI: 10.1101/2025.04.10.25322797

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