Article

Early-Life Sugar Restriction During the First 1000 Days and Adult Kidney Disease: A Natural Experiment with Phenotypic and Metabolomic Mediation

2026-05-07

Abstract excerpt

<h4>Background</h4> The first 1000 days from conception to age 2 years represent a critical window for kidney development, during which nutritional exposures may have lifelong programming effects. Whether early-life sugar restriction reduces long-term kidney disease risk remains unknown. <h4>Methods</h4> Using the UK sugar rationing policy (1942–1953) as a natural experiment, we compared risks of chronic kidney...

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Literature Corpus work: 28792054-6e80-5c84-ba1b-ff83dedb9169
DOI: 10.64898/2026.05.06.26352507

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