Article
Sugar rationing during the first 1000 days of life and lifelong risk of heart failure.
Nature communications - 21 Jan 2026
Tang Haoxian, Zhang Xuan, Huang Jingtao, Chen Xiaojing, Hong Jianan, Lin Hanyuan, Tian Cuihong, Nan Luo, Lin Mengyue, Yang Qinglong, Wu Shiwan, Chen Pan, Wen Jiasheng, Jiang Liwen, Zhang Youti, Wang Yali, Tan Xuerui, Chen Yequn
Abstract excerpt
Elevated sugar intake has been linked to poor cardiovascular health, but the effects of early-life sugar restriction on the lifelong risk of heart failure remain unclear. Using the end of sugar rationing in the United Kingdom in 1953 as a natural experiment, we classify participants in the UK Biobank by birth timing to define early-life exposure to sugar rationing. Here we show that individuals exposed to...
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