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Article

Theratyping cystic fibrosis in vitro in ALI culture and organoid models generated from patient-derived nasal epithelial conditionally reprogrammed stem cells.

The European respiratory journal - 1 Dec 2021

Sette Giovanni, Lo Cicero Stefania, Blaconà Giovanna, Pierandrei Silvia, Bruno Sabina Maria, Salvati Valentina, Castelli Germana, Falchi Mario, Fabrizzi Benedetta, Cimino Giuseppe, De Maria Ruggero, Biffoni Mauro, Eramo Adriana, Lucarelli Marco

Abstract excerpt

QUESTION: Cystic fibrosis (CF) is due to pathogenic variants in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Recent improvements have enabled pharmacological therapy aiming at restoring mutated CFTR expression and function. CFTR "modulators" have revolutionised the CF therapeutic landscape, particularly the last approved, Trikafta. This drug combination is indicated by the United States...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34413153
DOI: 10.1183/13993003.00908-2021
PMCID: PMC8675295

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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