Article

Profiling plasma extracellular vesicle-derived microRNAs for noninvasive diagnosis of alpha-1 antitrypsin deficiency associated liver disease

2023-09-01

Abstract excerpt

<h4>ABSTRACT</h4> Alpha-1 antitrypsin deficiency (AATD) is a rare genetic disease characterized by reduced circulating levels of alpha-1 antitrypsin (AAT) due to the retention of misfolded AAT in the hepatocytes. The toxic AAT aggregates in hepatocytes cause liver fibrosis, cirrhosis, and hepatocellular carcinoma. Most patients remain asymptomatic until the final stage in which liver transplantation becomes the o...

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Literature Corpus work: 27ed26b6-f9bd-5c7e-94f3-76bfdf4771b2
DOI: 10.1101/2023.08.31.555751

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