Article

Dispiro-indanedione hybrid of parthenin induces p53-independent apoptosis and suppresses tumor progression in colorectal cancer models

2026-01-27

Abstract excerpt

<title>Abstract</title> <p>Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide, with mutation of the p53 gene found in up to 80% of advanced CRC cases, resulting in apoptotic halt and significant drug resistance. The development of new drugs targeting the mutated p53 gene in CRC patients is limited. This study explored the anticancer potential of a dispiro-indanedione hybrid of p...

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Literature Corpus work: 26b20593-6afb-50f6-8aa7-8723873cffcb
DOI: 10.21203/rs.3.rs-8268375/v1

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Dispiro-indanedione hybrid of parthenin induces p53-independent apoptosis and suppresses tumor progression in colorectal cancer modelsDOI 10.21203/rs.3.rs-8268375/v1Read

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