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<i>SRRM2</i> haploinsufficiency drives SynGAP-γ reduction, <i>AGAP3</i> mis-splicing, and oligodendrocyte deficits in a mouse model of schizophrenia

2024-10-12

Abstract excerpt

<h4>SUMMARY</h4> Rare loss-of-function variants in SRRM2 , which encodes a nuclear speckle scaffold and splicing factor, are associated with schizophrenia and neurodevelopmental disorders. How SRRM2 haploinsufficiency disrupts brain function is unknown. We find that Srrm2 +/- mice exhibit (i) large-scale changes in gene expression in neuronal and glial cells, affecting DNA-binding-, synapse-, translation-, mi...

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Literature Corpus work
265f4f15-bfdf-57e2-b96d-95b61c5f6913
DOI
10.1101/2024.10.10.617460
Open publication

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<i>SRRM2</i> haploinsufficiency drives SynGAP-γ reduction, <i>AGAP3</i> mis-splicing, and oligodendrocyte deficits in a mouse model of schizophreniaDOI 10.1101/2024.10.10.617460
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