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Peripheral blood gene expression signatures of systemic immunity predict tumor microenvironment biology and therapeutic response in breast cancer

2025-07-07

Abstract excerpt

<title>Abstract</title> <p>This study investigates the association between peripheral blood immunological features and immunotherapy response in breast cancer. We generated and analyzed RNAseq data from 546 blood samples of patients with high-risk stage II/III HER2-negative breast cancer enrolled in the I-SPY2 trial and identified peripheral immune signatures associated with tumor characteristics and immunotherap...

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Literature Corpus work
262d9cc1-5af8-5a87-9771-436ded0b0e8c
DOI
10.21203/rs.3.rs-6926989/v1
Open publication

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Peripheral blood gene expression signatures of systemic immunity predict tumor microenvironment biology and therapeutic response in breast cancerDOI 10.21203/rs.3.rs-6926989/v1
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