Article

RNF213 variant and autophagic impairment: A pivotal link to endothelial dysfunction in Moyamoya disease

2023-10-16

Abstract excerpt

<h4>Background</h4> Moyamoya disease (MMD) is closely associated with the Ring Finger Protein 213 (RNF213), a susceptibility gene for this disease. However, its biological function remains unclear. We aimed to elucidate the role of RNF213 in the damage incurred by human endothelial cells under oxygen-glucose deprivation (OGD), a condition that mimics intracranial ischemia in patients with MMD. <h4>Methods</h4> W...

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Literature Corpus work: 25c8abef-4b69-5eaf-8b2c-8ecda47974ae
DOI: 10.1101/2023.10.11.561969

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