Article

Short-term, Long-term, and Genetic Determinants of Human Plasma Proteome Variability

2026-08-05

Abstract excerpt

Plasma proteomics is increasingly used for biomarker discovery and predictive modeling, yet diurnal protein trajectories remain insufficiently characterized. In our review of recent proteomic biomarker studies, 43% of the identified biomarkers had previously been reported to display 24-h rhythmicity. We demonstrate that ignoring these short-term dynamic effects compromises the robustness of reported models predict...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 25b89d7c-b8cd-5868-baa7-2f20bada8e42
DOI: 10.64898/2026.07.30.741635

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Short-term, Long-term, and Genetic Determinants of Human Plasma Proteome VariabilityDOI 10.64898/2026.07.30.741635Read

Circadian Rhythm of the Human Plasma ProteomeSemantic proximity Read

Facets of individual-specific health signatures determined from longitudinal plasma proteome profilingSemantic proximity Read

Facets of individual-specific health signatures determined from longitudinal plasma proteome profiling.Semantic proximity Read

Population-scale molecular reconstruction of human circadian phase from blood biomarkersSemantic proximity Read

Systematic discovery of gene-environment interactions underlying the human plasma proteome in UK BiobankSemantic proximity Read

Longitudinal analysis of genetic and environmental interplay in human metabolic profiles and the implication for metabolic healthSemantic proximity Read

Undulating changes in human plasma proteome across lifespan are linked to diseaseSemantic proximity Read

Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populationsSemantic proximity Read

Systematic discovery of gene-environment interactions underlying the human plasma proteome in UK Biobank.Semantic proximity Read

Long-term temporal stability of circulating proteins in older adultsSemantic proximity Read

Plasma Proteomic Determinants of Common Causes of MortalitySemantic proximity Read

Genetic drivers of protein changes over time: Findings, considerations, and approaches in TOPMed cohorts and UK BiobankSemantic proximity Read