Article

Heterogeneity in Multisystem Estrogenic and Site-Specific Microbiome Responses to Menopausal Hormone Therapy among Perimenopausal Women

2026-02-03

Abstract excerpt

<title>Abstract</title> <p>Menopausal hormone therapy (MHT) alleviates climacteric symptoms, but still, microbiome-wide effects and efficacy determinants remain uncharacterized. In this six-month longitudinal study of 356 perimenopausal women receiving oral MHT, we integrated serial clinical assessments with multi-site metagenomic profiling. MHT elicited multi-system estrogenic responses, including neuroendocrine...

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Literature Corpus work: 25339faa-a172-5bdc-a300-177c3294a515
DOI: 10.21203/rs.3.rs-8555097/v1

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Heterogeneity in Multisystem Estrogenic and Site-Specific Microbiome Responses to Menopausal Hormone Therapy among Perimenopausal WomenDOI 10.21203/rs.3.rs-8555097/v1Read

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