Article

Loss of KMT2D accelerates hypertrophic chondrocyte differentiation and senescence by increasing mitochondrial ROS production

2026-03-19

Abstract excerpt

Longitudinal bone growth occurs through endochondral ossification, which is accompanied by the differentiation of chondrocytes in the growth plate. Disruption in chondrocyte maturation can lead to skeletal growth abnormalities, such as those observed in Kabuki syndrome type 1 (KS1), a genetic disorder caused by heterozygous pathogenic variants in the KMT2D gene. KS1 patients exhibit postnatal growth deficiency, c...

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Literature Corpus work: 2529b277-cfa9-5cb6-a581-b4f61de057e3
DOI: 10.64898/2026.03.18.712470

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