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Article

Exosomes from high glucose-treated glomerular endothelial cells trigger the epithelial-mesenchymal transition and dysfunction of podocytes.

Scientific reports - 24 Aug 2017

Wu Xiaoming, Gao Yanbin, Xu Liping, Dang Wanyu, Yan Huimin, Zou Dawei, Zhu Zhiyao, Luo Liangtao, Tian Nianxiu, Wang Xiaolei, Tong Yu, Han Zheji

Abstract excerpt

New data indicate that abnormal glomerular endothelial cell (GEC)-podocyte crosstalk plays a critical role in diabetic nephropathy (DN). The aim of our study is to investigate the role of exosomes from high glucose (HG)-treated GECs in the epithelial-mesenchymal transition (EMT) and dysfunction of podocytes. In this study, exosomes were extracted from GEC culture supernatants and podocytes were incubated with the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28839221
DOI: 10.1038/s41598-017-09907-6
PMCID: PMC5571220

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