Back to search

Article

Mast cell activation is enhanced by Tim1:Tim4 interaction but not by Tim-1 antibodies

2016-07-08

Abstract excerpt

Polymorphisms in the T cell (or transmembrane) immunoglobulin and mucin domain 1 ( TIM-1 ) gene, particularly in the mucin domain, have been associated with atopy and allergic diseases in mice and human. Genetic- and antibody-mediated studies revealed that Tim-1 functions as a positive regulator of Th2 responses, while certain antibodies to Tim-1 can exacerbate or reduce allergic lung inflammation. Tim-1 can als...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
25088319-997f-5970-a4c3-feeb8e7185eb
DOI
10.12688/f1000research.8132.2
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Mast cell activation is enhanced by Tim1:Tim4 interaction but not by Tim-1 antibodiesDOI 10.12688/f1000research.8132.2
TIM-1, a novel allergy and asthma susceptibility gene.Semantic proximity
Suppression of mast cell degranulation through a dual-targeting tandem IgE-IgG Fc domain biologic engineered to bind with high affinity to FcγRIIb.Semantic proximity
FcεRI: A Master Regulator of Mast Cell FunctionsSemantic proximity
The costimulatory role of TIM moleculesSemantic proximity
The association of the exon 4 variations of Tim-1 gene with allergic diseases in a Korean population.Semantic proximity
TIM family of genes in immunity and tolerance.Semantic proximity
Mast Cell Modulation of B Cell Responses: An Under-Appreciated Partnership in Host DefenceSemantic proximity
Deciphering the structure and function of FcεRI/mast cell axis in the regulation of allergy and anaphylaxis: a functional genomics paradigmSemantic proximity
Mast Cells and IgE: From History to TodaySemantic proximity
Widespread immunological functions of mast cells: fact or fiction?Semantic proximity
T Cell, Ig Domain, Mucin Domain-2 Gene-Deficient Mice Reveal a Novel Mechanism for the Regulation of Th2 Immune Responses and Airway InflammationSemantic proximity
A TNFRSF14-FcɛRI-mast cell pathway contributes to development of multiple features of asthma pathology in mice.Semantic proximity
Select a neighboring publication to make it the new centre.