Article

Pre and Post antibiotic epoch: insights into the historical spread of antimicrobial resistance

2024-09-04

Abstract excerpt

Plasmids are now the primary vectors of antimicrobial resistance, but our understanding of how human industrialisation of antibiotics influenced this is limited by a paucity of data predating the antibiotic era (PAE). By investigating plasmids from clinically relevant bacteria isolated between 1917 and 1954 and comparing them to modern plasmids, we captured over 100 years of evolution. We show that while all PAE p...

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Literature Corpus work: 24b73098-8694-5b06-8478-a00be50f9347
DOI: 10.1101/2024.09.03.610986

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