Article

A Treatment-Resistant Severe Asthma Phenotype with Dysregulated Hippo Pathway as Shown by Sputum Transcriptomics and Proteomics

2025-05-13

Abstract excerpt

Severe asthma is a heterogeneous condition often resistant to conventional corticosteroid therapy, necessitating the identification of novel biomarkers and therapeutic targets. This study investigates immunological, transcriptional, and proteomic biomarkers in severe asthma patients from the Brazilian ProAR cohort. Cytokines were measured using a multiplex technology (Luminex, Merck) and the differential sputum ce...

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Literature Corpus work: 23b7eada-3c80-5580-ac8b-80e0aa8d8833
DOI: 10.20944/preprints202505.1001.v1

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